Abstract
In the present study we investigated the direct actions of ethanol on the membrane properties and excitatory and inhibitory postsynaptic potentials of trigeminal motoneurons in chronic cats. During states of sleep and wakefulness, extracellular and intracellular recordings were carried out together with juxtacellular (somatic and dendritic) and intracellular pressure injections of 0.05–2.5 M ethanol solutions in femtoliter quantities. Juxtacellulary applied ethanol induced: (1) a sequence of excitatory-inhibitory alterations in firing activity which were accompanied by depolarizing-hyperpolarizing shifts in the resting membrane potential; (2) a decrease in the amplitude of action potentials; and (3) a depression in excitatory and inhibitory postsynaptic potentials. Intracellular ethanol injections resulted in depolarization of the membrane potential and a decrease in the amplitude of action potentials as well as a reduction in the amplitude of excitatory and inhibitory postsynaptic potentials. Both juxtacellularly applied ethanol affected the membrane potential and synaptic activity in a fashion that was not dependent upon the animal's behavioral state of sleep or wakefulness.
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