Abstract
Ethanolamine is used as an energy source by phylogenetically diverse bacteria including pathogens, by the concerted action of proteins from the eut-operon. Previous studies have revealed the presence of eutBC genes encoding ethanolamine-ammonia lyase, a key enzyme that breaks ethanolamine into acetaldehyde and ammonia, in about 100 bacterial genomes including members of gamma-proteobacteria. However, ethanolamine utilization has not been reported for any member of the Vibrio genus. Our comparative genomics study reveals the presence of genes that are involved in ethanolamine utilization in several Vibrio species. Using Vibrio alginolyticus as a model system we demonstrate that ethanolamine is better utilized as a nitrogen source than as a carbon source.ReviewersThis article was reviewed by Dr. Lakshminarayan Iyer and Dr. Vivek Anantharaman (nominated by Dr. L Aravind).
Highlights
Ethanolamine is used as an energy source by phylogenetically diverse bacteria including pathogens, by the concerted action of proteins from the eut-operon
It has been seen in Salmonella enterica that all essential proteins for ethanolamine metabolism are clustered into a multiprotein complex known as the metabolosome, which is reminiscent of the bacterial microcompartment [5]
Though sequences of genes encoding EutB and EutC have been reported in nearly 100 bacterial genomes [4], no functional eut operon has been reported in Vibrio
Summary
Ethanolamine is used as an energy source by phylogenetically diverse bacteria including pathogens, by the concerted action of proteins from the eut-operon. Though sequences of genes encoding EutB and EutC have been reported in nearly 100 bacterial genomes (including several Gammaproteobacteria such as Escherichia coli, Acinetobacter baumannii, Pseudoalteromonas atlantica) [4], no functional eut operon has been reported in Vibrio.
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