Abstract
Ethanol withdrawal enhances the current density of calcium (Ca 2+) channels in inferior colliculus (IC) neurons. The present report shows that ethanol withdrawal markedly enhanced the susceptibility to seizures as it decreased significantly the protein levels of α 1B subunit associated with N-type Ca 2+ channel in IC neurons of animals not tested for seizures. Thus, remodeling of N-type Ca 2+ channels may play an important role in neuronal hyperexcitability that leads to ethanol withdrawal seizures.
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