Abstract
Abstract Alcoholic myopathy affects 40–60% of long-term alcoholics and is more prevalent than other common alcohol-related diseases, such as cirrhosis of the liver. The process by which ethanol consumption leads to the development of myopathy in skeletal muscle is not well understood, and multiple factors are thought to contribute to the progression of the disease. A key event in the formation of skeletal muscle is the fusion of myoblasts to form multinucleated muscle fibers. There are conflicting reports in the literature with regard to the effect of alcohol on fusion of myoblasts during differentiation. The purpose of this study was to address this discrepancy by assessing the effect of ethanol on the differentiation of C2C12 skeletal muscle cells, utilizing the fusion index calculation as a measurement of differentiation. Our results demonstrate a significant reduction in the fusion of myoblasts when they are treated with a physiologically relevant concentration of ethanol at the start of differentiation.
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