Abstract
Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispermaceae) is a plant used to treat respiratory diseases. The aim of this study was to evaluate the effect of Cissampelos sympodialis extract (CSE) in lungs of diabetic rats. We used 30 Wistar rats divided into three groups: control group (CG), diabetic group (DG) and diabetic Cissampelos sympodialis treatment group (DTG). Diabetes was induced by streptozotocin (40 mg/kg i.v.). The CSE (400 mg/kg, po) was administered daily, during four weeks, beginning one week after the onset of DM. The treatment with CSE was not able to reduce blood glucose levels after streptozotocin injection. However, it was able to decrease cholesterol and triglycerides and prevent damage on pancreatic islets morphology. Additionally, morphological alterations such as alveolar septa loss, inflammatory infiltrate and fibrosis were seen in lung tissue of rats with DM, and treatment with CSE apparently reversed these histopathological findings. Thus, CSE treatment reduced the lipid profile and restored the lung architecture of diabetic animals by a mechanism independent of glycemia and which might be associated with the reduction of the damage on the pancreatic islets.
Highlights
Diabetes Mellitus (DM) is a diffuse endocrine disease, characterized by metabolic abnormalities and long-term complications due to hyperglycemia
30% of all newborn children have the genetic risk for type 1 DM and a smaller percentage of those children progress to the clinical disease (MejíaLeón et al, 2015)
Four weeks after STZ-induced DM, there was a significant increase in fasting glycemia in the diabetic group (DG) compared to the control group (CG) group (p
Summary
Diabetes Mellitus (DM) is a diffuse endocrine disease, characterized by metabolic abnormalities and long-term complications due to hyperglycemia. 30% of all newborn children have the genetic risk for type 1 DM and a smaller percentage of those children progress to the clinical disease (MejíaLeón et al, 2015). Additional factors are involved in type 1 DM pathogenesis, such as viral infections, intestinal inflammation, and nutritional factors, which are required to trigger the disease in genetically predisposed individuals (Kinip, Simell, 2012).
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