Abstract
The combination of herb medicine is alternative option in hypertension because it has more potential for treatment with complications like hyperlipida. Plant which can be used for anti-hypertension therapy is combination of celery herb (Apium graveolens) and bay leaf ethanol extract (Syzygium polyanthum). This research aims to determine the activity of a combination of celery herb ethanol extract (CHEE) and bay leaf ethanol extract (BLEE) and find out how much the decrease of blood pressure on the combination of both toward hypertension with high fat Wistar mice. The design of this research used an experimental design with pre-post control group design. Hypertensive mice are induced with high fat feed and orally with sodium chloride 8%, then the mice are supplied with combinations extract with the dose of 1.125 ; 6.25 ; 2.25 ; 12.5 and 4.5 ; 25 mg/kg, hydrochlorotiazide 2.25 mg/kg, Simvastatin 0.9 mg/kg, CHEE 4.5 mg/kg, BLEE 25 mg/kg and CMC-Na 0.5%. Research result shows that the combination can decrease systole blood pressure in the 22nd day. The extract combination has anti-hypertension effect (it is able to decrease systole blood pressure ≥ 20 mmHg) and it is not significantly different with normal group (p<0.05). Based on the research, it can be concluded that ethanol extract combination can decrease systole blood pressure with high fat complications after using it for 22 days.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.