Abstract
Introduction: Pegagan embun (Hydrocotyle sibthorpioides L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (Hydrocotyle sibthorpioides L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. Methods: Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (Hydrocotyle sibthorpioides L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. Results: The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p <0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p <0.05). Conclusion:It can be concluded that the extract of pegagan embun (Hydrocotyle sibthorpioides L.) can be used to treat anemia in male white mice.
Highlights
Pegagan embun (Hydrocotyle sibthorpioides L.) is known to have many benefits, including as a blood booster
The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p
Anemia is a condition in which decreased hemoglobin (Hb), hematocrit, and red blood cell counts are below normal values[6]
Summary
Blood is an essential component of living things that function as a medium of communication between cells. Anemia is a condition in which decreased hemoglobin (Hb), hematocrit, and red blood cell counts are below normal values[6]. Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice. Et al.: Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice is pegagan embun[16]. There has been no research on the ethanol extract of pegagan embun on anti-anemia activity. Insert the micro capillary tube into a centrifuge (microhematocrit centrifuge), centrifuge at 1000 rpm for 5 minutes It calculates the hemoglobin level using a hemoglobin measuring device (brand Easy Touch GHb) by checking the tools to be used, namely the hemoglobin meter installed with a strip and taking the blood of the experimental animals. The data were tested for normality and continued with the two-way ANOVA method and the Duncan test
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