Abstract
Enhanced penetration by ethanol of exogenous arachidonic acid into human leukocyte preparations results in the production of large amounts of eicosanoids including 5-, 12- and 15-hydroxyeicosatetraenoic acids as well as the leukotrienes C 4 Δ 6- trans-leukotriene B 4, 12-epi-Δ 6- trans-leukotriene B 4, leukotriene B 4 and 5(S), 12(S)-dihydroxyeicosatetraenoic acid. The production of these compounds is affected by the concentrations of both ethanol and arachidonic acid independently in a complex manner with stimulation at lower concentrations and later relative inhibition. It was shown that the resulting leukotriene B 4 exhibited the same specific activity as exogenous arachidonic acid when labelled substrate was used.
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