Abstract
Ethanol consumption affects maternal nutrition, the mothers’ antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny’s weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.
Highlights
It is known that ethanol consumption compromises oxidative stress and nutritional status [1]
In this study we have found that AO have higher Se levels in serum and higher glutathione peroxidase (GPx) activity than those found in the rest of the groups
GPx activity in liver was opposite to that which occurs in serum; it decreases hepatic Se levels and GPx activity, making it evident that oxidative stress is affected in pups whose mothers drank ethanol during gestation and lactation, and that this effect is related to Se levels
Summary
It is known that ethanol consumption compromises oxidative stress and nutritional status [1]. There is increasing evidence that Se is vital for foetal and neonatal development This is demonstrated by the embryonically lethal consequences of the disruption of the gene coding for the Sec tRNA[Ser]Sec, suggesting an essential function for one or more selenoproteins in development [8]. We have recently observed that pups exposed to ethanol during gestation and lactation have their hepatic antioxidant activity altered, provoking a decrease in Se and GPx activity, and an increase in carbonyl groups in protein. The objective of this study was to examine the bioavailability of Se in both dams exposed to ethanol during gestation and lactation and in their progeny In this context we will evaluate the activity of the antioxidant enzyme GPx in pups’ serum and liver, and the relationship with maternal nutrition
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
