Ethanol Consumption and Sepsis: Mechanisms of Organ Damage

doi:10.33696/signaling.2.056

Abstract

Sepsis is highly prevalent, and is one of the main causes of mortality among hospitalized patients. Ethanol consumption in large quantities compromises the normal functioning of the body, leading to dysfunction of multiple different organ systems.

Highlights

Sepsis is considered one of the main causes of death in the world, and can be aggravated by acute or chronic exposure to ethanol [1], directly affecting vascular function [2]
The main pathogenic mechanisms implicated in both sepsis and ethanol consumption involve the activation of the immune system, releasing anti-inflammatory and pro-inflammatory mediators, as well as the activation of the antioxidant system [1,5,7,8], which has been demonstrated in both animal and human studies [2,5,9,10]
The focus of this review is to address the main mechanisms between increased sepsis mortality associated with ethanol consumption, giving an overview of the inflammatory processes involved

Summary

Introduction

Sepsis is considered one of the main causes of death in the world, and can be aggravated by acute or chronic exposure to ethanol [1], directly affecting vascular function [2]. The focus of this review is to address the main mechanisms between increased sepsis mortality associated with ethanol consumption, giving an overview of the inflammatory processes involved. The association of ethanol consumption with sepsis and the mechanisms involved between increased mortality seen in alcoholic patients to sepsis is still quite controversial.

Results

Conclusion