Abstract
Neurite-producing cultured embryonic chick brain neurons in 96-h culture were exposed chronically to 25 mM ethanol for a 72-h period. Neurital plasma membrane extension was markedly attenuated in the ethanol-exposed neurons as compared with ethanol-free control cultures. The rate of biosynthetic sialylation of gangliosides, which are major structural sialoglycosphingolipid components in the exofacial lipid bilayer of the neurital plasma membrane, decreased to about half that in the alcohol-free neurons. The findings show that ganglioside sialylation in the morphodifferentiating central nervous system neuron is significantly attenuated by chronic exposure to a moderate dose of ethanol. Depression of ganglioside-dependent neuritogenesis may represent a mechanism for development of the central nervous system component of the fetal alcohol syndrome.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
