Abstract
Etanercept induces remission of polyarteritis nodosa: a case report.
Highlights
Polyarteritis nodosa (PAN) is a systemic autoimmune vasculitis characterized by necrotizing inflammatory lesions of the medium-sized and small muscular arteries, preferentially at vessel bifurcations, resulting in microaneurysms formation, aneurysmal ruptures with hemorrhage, thrombosis and organs ischemia or infarction
Rituximab works by affecting the action of and eliminating B cells, which are cells of the immune system that have a number of actions
It was initially developed for treatment of a type of lymphoma, and since has been found to be effective for autoimmune diseases, including rheumatoid arthritis and ANCA-associated vasculitis (Cohen Tervaert, 2011)
Summary
Polyarteritis nodosa (PAN) is a systemic autoimmune vasculitis characterized by necrotizing inflammatory lesions of the medium-sized and small muscular arteries, preferentially at vessel bifurcations, resulting in microaneurysms formation, aneurysmal ruptures with hemorrhage, thrombosis and organs ischemia or infarction. Skin lesions, characterized by multiple firm waxy papules, subcutaneous nodules, livedo reticularis, ulcers and gangrene, are observed in 25–60% of patients with PAN (Cohen et al, 1980). In most of the cases, the disease is treated with glucocorticoids and cyclosphosphamide (conventional treatment).
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