Abstract
A diethylzinc-mediated radical (3 + 2) cycloaddition of vinyl azides with ethyl iododifluoroacetate is presented. The developed reaction features good functional group tolerance, broad substrate scope, and operational simplicity, enabling efficient assembly of a wide range of 3,3-difluoro-γ-lactam derivatives bearing an O-substituted quaternary carbon center in moderate to good yields. The utility of the method is showcased by a scaled-up reaction, conversion of the product, and late-stage structural modifications of a variety of pharmaceutical compounds.
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