Abstract
The present work aims to study the degradation of Nabumetone through direct photolysis. Solutions of Nabumetone in ethanol (20 mg/mL) were prepared and divided in quartz cuvettes with teflon lids. These were placed in the photolysis cabinet at 35oC. The photodegradation quantifications were analyzed in High Performance Liquid Cromatography (HPLC); after 47 days of photolysis the sample degradation was 67%, after 73 days 88.5% and after 111 days 89.5%. Spectrophotometers determinations (240 to 360 nm) were accomplished after 28, 47 and 73 days of photolysis. The photoproducts were separate for HPLC and analyzed by Gas Cromatograph coupled to Mass Spectrometer (GC-MS). The analysis in GC-MS of the Nabumetona photolyseded for 111 days allowed the suggestion of two substances.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
