Estudio del aclaramiento de la infección por el VPH de alto riesgo después de una conización

Abstract

ObjectiveTo evaluate the percentage of clearance of high-risk HPV infection in women undergoing cervical conization, as well as to analyse the most prevalent HPV genotypes in our environment. Material and methodsLongitudinal, observational, retrospective, descriptive and analytical study. The conizations performed in Area 7 of the Hospital Clínico San Carlos in Madrid between October 2015 and October 2016 were reviewed. ResultsOf 291 conizations over 12 months, pre-conization HPV-AR determination was made in 138 patients. In 247 patients the indication for excisional treatment was the result of biopsy HSIL/CIN 2-3, and in 44 for persistent LSIL/CIN 1 for more than 2 years. Sixty-one of the 138 women had one or more HPV-AR other than 16/18/31 prior to conization (61/138), while 77 patients were diagnosed with HPV-AR 16/18/31 (77/138). If we break it down, HPV 16 was present in 58/138 of cases, HPV 31 in 15/138 and HPV 18 in 4/138. In the first post-conization control, in 126 patients the determination of HPV-AR was negative (126/138). Clearance of HPV 16 was achieved in 49 patients (49/58), HPV 31 in 13 (13/15) and HPV 18 in 1 (1/4). ConclusionsGenotype 16 was the most common HPV-AR in conized women in our study, followed by 31 and 18. After cervical conization, a clearance of HPV-AR infection was achieved in 91.4% of patients.