Estudio de selección de microRNA como posibles biomarcadores de aneurisma de aorta abdominal

Abstract

IntroductionMicroRNAs (miRs) are small RNA molecules that are involved in several biological processes. Due to their stability and their presence in biological fluids, several studies over the last few years have focused on the use of miRs as biomarkers of different pathologies. ObjectiveSelection of a group of miRs candidates to be validated as potential biomarkers of abdominal aortic aneurysm (AAA). Material and methodsA total of 179 miRs were quantified in 7 patients with AAA and in 7 healthy donors, using predesigned panels based on RT-qPCR technology. ResultsA total of 10 miRs, dysregulated in patients, were selected as good candidates for studying them as biomarkers. It has been observed that most of these miRs participate in several biological processes related to the formation and development of AAAs. ConclusionAdditional, as well as validation, studies are needed, but some of these miRs could be non-invasive AAA biomarkers.