Estudio comparativo de los efectos de dos drogas antiglaucomatosas sobre el espesor corneal en conejos con autoinjerto de córnea

Abstract

To determine the central corneal thickness after administration of the anti-glaucomatous medications latanoprost 0.005% or dorzolamide 2%, as assessed in rabbits which have had total corneal thickness autografts. A bilateral total corneal thickness autograft was performed in ten rabbits. One rabbit was excluded from the subsequent study in which the antiglaucomatous medication was started two months post-operatively. Latanoprost 0.005% was instilled once per day into the right eye, whereas the left eyes were treated with dorzolamide 2% twice a day. The eyes were examined by biomicroscopy and ultrasound pachymetry immediately prior to commencement, and 4, 10, 17 and 27 weeks after starting the anti-glaucomatous treatment. In each instance three assessments of the central corneal thickness in each eye were made. At the end of the study, the influence of time and treatment on the corneal thickness was analyzed using a generalized linear model for repeated measurements. All penetrating keratoplasties were performed by the same surgeon (C.H.P). Treatment with dorzolamide resulted in corneal edema and a significant increase in central corneal thickness, whereas the treatment with latanoprost resulted in neither corneal edema nor corneal thickness changes. Dorzolamide, when instilled into the eyes of rabbits with corneal autografts, could have a negative effect on the graft, impairing the endothelial function through inhibition of the ionic pump. This effect could cause graft failure, which may be able to be defined with ultrasound pachimetry.