Abstract
Effects of midazolam intraperitoneally (3.0 mg/kg) administered, or locally applied into lateral septal nuclei (10 μg/μl), or into the medial septum (10 μg/μl) were assessed in Wistar rats during late proestrus or metestrus–diestrus in a conflict-operant task. A reduction in conflict behavior was found in control rats during late proestrus ( P<.05), when compared to metestrus–diestrus. Systemic injections of midazolam ( P<.05) or midazolam infusions into lateral septal nuclei ( P<.05) also reduced conflict behavior only during late proestrus, whereas midazolam infusions into the medial septum produced neither of these anticonflict effects in any estrous phase. In conclusion, an endocrine-related variation in anticonflict effects of midazolam microinjected into lateral septal nuclei was displayed by female rats.
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