Estrogens, Progestins, and Their Antagonists

Abstract

I: New Applications and Concepts Involving Estrogens and Progestins.- 1. Benefits and Risks of Hormone Replacement Therapy.- 2. Phytoestrogen Effects in Humans Relative to Risk for Cardiovascular Disease, Breast Cancer, Osteoporosis, and Menopausal Symptoms.- 3. Dietary Indoles with Antiestrogenic Activity in Common Vegetables and Their Implications.- 4. Treatment for Infertility and Risk of Female Cancers.- 5. Antiestrogen Resistance in Human Breast Cancer.- 6. Evolving Therapies for Prostatic Carcinoma, Encompassing Orchiectomy, Estrogens, and Estramustine.- 7. Regulatory Aspects of Estrogens and Progestins in Human Food: Past, Present, and Future.- II: Novel Hormonal Ligands.- 8. Estrogen and Progestin Radiopharmaceuticals for Imaging Breast Cancer.- 9. The Utility of Fluorescent Estrogens for Receptor Imaging.- 10. Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel and Gestodene and Older Oral Contraceptives.- 11. Antiprogestins: Past, Present, and Future.- I: Estrogen and Progestin Physiological Function.- 1. Pituitary and Brain Actions of Estrogen and Progesterone in the Regulation of Primate Prolactin Secretion.- 2. Saccharomyces cerevisiae As a Model System to Study Steroid Hormone Receptors.- 3. Physiological Findings from Transgenic Mouse Models with Altered Levels of Estrogen Receptor Expression.- II: Molecular Biology of Steroid Receptors and Gene Expression.- 4. New Models and Insights in Steroid Hormone Action.- 5. A Role for Progesterone in Multidrug Resistance.- 6. Dominant Negative Activity by Estrogen and Progesterone Receptors.- 7. Estrogen and Progesterone Receptors in Human Endometrial Cancer.- III: Factors Enhancing Receptor Function.- 8. Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group Protein-1: Protein Manipulation of DNA Structure.- 9. Use of FK506 and Its Analogs in Studying Progesterone Signaling.- Keyword Index.- Keyword Index.