Abstract
We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(phydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17 (E 2 ), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E2 (100%) were 1.3‐ 1.4% and 0.00010‐0.00023%, respectively. These findings indicated that MBP has about 10 4 -fold higher estrogenic potency than the parent BPA and about 1/50 that of E2 for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
