Abstract
While investigating the estrogenic properties of the pesticide Fosmet administered to neonatal rats we found that a 10% emulsion concentrate of Tween 80 can increase the mean relative weight of the uterus and cause changes in the endometrium that are characteristic of the action of estrogens (Gajdovaet al., 1988). In the rats exposed to Tween 80 we found a significant prolongation of the oestrous cycle and persistent vaginal estrus in adulthood (Vargova et al., 1990). Similar changes after the application of some substances with estrogenic effect were; described by Bulger and Kupfer (1985).
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