Abstract
Schwenk and Hildebrandt1 described the isolation from the urine of pregnant mares of a new compound of high estrogenic potency. This substance, designated by them δ- follicular hormone, melted at 209°, gave a characteristic purple color when coupled with p-nitro-diazobenzene and showed a gold yellow fluorescence in concentrated sulfuric acid solution. Analysis of the compound itself and of its mono-benzoate indicated the composition C18H22O2. Treatment with ketone reagents failed to give characteristic derivatives.Another batch of pregnant mare's urine has now been worked up in the laboratories of the Schering Corporation (Bloomfield, N. J.). The compound present in largest amount in the crude fraction containing the phenol-alcohols is the above δ-follicular hormone. Analysis of the present preparation gave figures agreeing better with C18H24O2 than with C18H22O2. The preparation of a di-p-nitro-benzoate (m.p. 260° uncorr.) leaves no doubt that both oxygen atoms are present in the form of hydroxyl groups....
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
