Abstract
AbstractA petroleum ether soluble fraction Fr. III isolated from the benzene extract of Malvaviscus conzattii Greenum flowers and administered orally to adult female rats at the doses of 10, 20 and 40 mg/rat from day 1 to day 5 of pregnancy showed 50%, 60% and 80% anti‐implantation, as well as 60%, 80% and 100% anticonceptive activity in the treated animals, respectively. There was a dose dependent termination of pregnancy and reduction in the number of implantation sites. In ovariectomized young female rats, the Fr. III exhibited estrogenic activity at comparable anticonceptive doses, but was devoid of antiestrogenic activity. Fr. III seems to possess a weak estrogenic activity in that a significant uterotrophic effect was discerned even at 1/16th of the anticonceptive dose.
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