Abstract
IN PREVIOUS COMMUNICATIONS (1–4) physiological effects of the ovarian hormones on the histological components of the human cervical mucosa were reported, and also observations made on the atrophic cervical mucosa of castrated women following ovarian hormonal treatment. It was shown that estrogen has a specific growth stimulating effect on the columnar epithelial elements, which can be depressed by the simultaneous administration of progesterone. Estrone and progesterone, when given simultaneously, produce a markedly increased growth in the squamous epithelium of the cervix. In all of my cases the proliferation of the two epithelial ele-ments was found to be orderly under ovarian hormonal stimulation. When estrone is given in suf-ficient amounts to a castrated woman, the atrophic cervical mucosa is changed into a structure which presents the typical picture of glandular hyperplasia. The clinical and histological picture of socalled endocervicitis and erosion can be produced in dry, atrophic cervices by lon...
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