Abstract
[ 3H]-diethylstilbestrol has been injected into pregnant mice on day 16 of pregnancy. Autoradiograms were prepared from fetal tissues as well as maternal brain. Radioactivity is found to be concentrated in the male and female fetus in nuclei of cells in certain hypothalamic and extrahypothalamic brain regions, in the anterior pituitary, in laryngeal mesenchyme, in mesenchyme that surrounds the genital tracts, the urogenital sinus, the rectum and the mammary glands, in the gubernaculum testis, and in the skin. The results suggest presence of estrogen receptors in these structures and estrogenic actions at these sites.
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