Abstract
Preclinical studies support the protective effects of estrogens against cardiovascular disease; however, hormone replacement therapy trials are inconsistent. One hypothesis for these discrepancies are the differences in therapy timing. Interestingly no study has examined the chronological myocardial changes associated with menopause. This study is the first to identify changes in estrogen receptor (ER) regulation of the heart using a unique mouse model involving gradual ovarian failure to capture peri-menopause.
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