Abstract
Protocadherin‑8 (PCDH8) is a member of the protocadherin subfamily within the cadherin superfamily of cell adhesion molecules. PCDH8 is silenced in a variety of solid tumors including those of the breast, and believed to be a tumor suppressor. Here we show that PCDH8 is suppressed by estrogen in MCF-7 and T47D breast cancer cells. The suppression is dependent on estrogen receptor‑α (ERα) expression. Knockdown of ERα alone induces the expression of PCDH8. The inverse correlation between PCDH8 and ERα expression is also apparent from the analysis of PCDH8 expression in breast tumors from the TCGA-BRCA dataset. Since estrogen produces mitogenic effects in ERα positive breast cancer cells, estrogen-mediated suppression of PCDH8 is consistent with its purported tumor suppressor function. Functional studies on PCDH8 in breast cancer cells may yield valuable insights into the mechanisms of estrogen-mediated epithelial-mesenchymal transition.
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