Abstract
IT HAS BEEN SHOWN that the urinary estrogens of normal non-pregnant women, when extracted after optimum conditions of hydrolysis and separated into estrone (weak phenolic) and estriol (strong phenolic) fractions, will vary in concentration during the menstrual cycle, and almost invariably have higher activity in the estrone fraction (1, 2). In rabbits (3, 4) injected estrone becomes in part converted to estriol in normal females but not in ovariectomised females or in females lacking uteri. The simultaneous injection of estrone plus progesterone into rabbit females results in an increased urinary estrogen output (5) and a furthering of the estrone-estriol conversion (3). This appears to occur also in women (2). We have determined the urinary estrogen in a series of 5 non-cancerous and 7 cancerous women before and after the injection of estrone (2.1 mg.) and estrone (2.1 mg.) plus progesterone (10 mg.). The hormones were administered in a single intramuscular injection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
