Abstract
Objective: The mechanism of estrogen action on breast cancer cell growth is poorly understood. Expression of the p53 gene protects cells against malignant transformation; cells that develop mutations in p53 demonstrate a diminished apoptotic potential, which may contribute to tumor growth and metastasis. The factors that regulate p53 expression are poorly characterized. HOXA10 is a homeobox gene that we have previously shown to be expressed in response to sex steroids in the uterus and is essential for implantation. Here we investigate the possibility that HOXA10 mediates estrogen action and p53 expression in breast cancer.
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