Abstract
RNA extracted from estrogen-stimulated oviduct is demonstrated to code for synthesis of 14C-ovalbumin in a cell-free rabbit reticulocyte lysate system. Ovalbumin mRNA is concentrated in an 8–17S fraction isolated from polysomes. Oviduct rRNA or chick liver RNA does not direct ovalbumin synthesis. Hen oviduct contains large quantities of ovalbumin mRNA. Undetectable amounts are present in oviducts of immature chicks but ovalbumin mRNA can be induced in immature animals by estrogen. Finally, hormone withdrawal results in disappearance of ovalbumin mRNA. Readministration of estrogen results in a marked accumulation of ovalbumin mRNA activity. This report constitutes the initial documentation of the hormone-induced synthesis of a specific mRNA and its translation in a heterologous system.
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