Abstract
BackgroundRecent studies have suggested that estrogen (E2) plays an important role in epithelial ovarian cancer (EOC). However, the mechanism of E2 in ovarian cancers is unclear. The purpose of this study was to investigate the effect of E2 on ovarian cancers and illuminate the mechanism of E2 in promote ovarian cancers proliferation.ResultsWe demonstrated that E2 stimulated the proliferation and invasion of ovarian cancer cells. In this study, ovarian cancer specimens were also analyzed for transient receptor potential channel C3 (TRPC3) expression; TRPC3 expression levels were higher in ovarian cancer samples than in normal ovarian tissue samples. Previous studies have shown that TRPC3 contributes to the progression of human ovarian cancer. In this study, we further investigated the interaction between E2 and TRPC3. We found that E2 stimulation enhanced the expression of TRPC3 at both the mRNA and protein levels. E2 stimulation enhanced the influx of Ca2+. Moreover, siRNA-mediated silencing of TRPC3 expression inhibited the ability of E2 to stimulate the influx of Ca2+.ConclusionsIn conclusion, TRPC3 plays a significant role in the stimulatory activity of E2 and could be a therapeutic target for the treatment of EOC. Furthermore, this study elucidates the molecular mechanism by which E2 promotes the proliferation and migration of EOC cells.
Highlights
Epithelial ovarian cancer (EOC) is the most common type of gynecological cancer
E2 promoted the proliferation and migration of different ovarian cancer cells To investigate the function of estrogen receptor (ER)-α in ovarian cancer, we detected the expression of ER-α in different ovarian cancer cell lines
The Transwell assays showed that SKOV3 and HEY cell migration was significantly increased under E2 conditions (Fig. 1c and d and Fig.1e and f)
Summary
Epithelial ovarian cancer (EOC) is the most common type of gynecological cancer. 230,000 women worldwide will be diagnosed with EOC, and 150,000 will die [1]. EOC represents the seventh most commonly diagnosed cancer among women globally and has a 46% 5year survival rate after diagnosis. One of the main factors contributing to the high death-to-incidence ratio is the advanced stage of disease at the time of diagnosis [2]. The cause of this disease is not clear. Recent studies have suggested that estrogen (E2) plays an important role in epithelial ovarian cancer (EOC). The mechanism of E2 in ovarian cancers is unclear. The purpose of this study was to investigate the effect of E2 on ovarian cancers and illuminate the mechanism of E2 in promote ovarian cancers proliferation
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