Abstract
BackgroundChronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice.MethodsForty eleven-week-old female C57BL mice were used in this study. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination.ResultsAll the mice survived the experimental period. Serum measurements confirmed a significant increase in BUN in the CKD group that was further increased by OVX. OVX led to significant decreases in both the BV/TV and cortical thickness of the mandibular bone in CKD mice.ConclusionIn summary, our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice.
Highlights
Chronic kidney disease (CKD), which is a grave health problem, affects millions of individuals worldwide [1,2,3]
OVX led to significant decreases in both the bone volume/tissue volume (BV/TV) and cortical thickness of the mandibular bone in CKD mice
Our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice
Summary
Chronic kidney disease (CKD), which is a grave health problem, affects millions of individuals worldwide [1,2,3]. CKD patients are predicted to develop impaired bone metabolism that leads to CKD mineral and bone disorder (CKD-MBD), which is characterized by cortical loss and trabeculation [4,5,6]. Such changes triggered by CKD were previously reported to alter mandibular bone remodeling [7, 8], eventually leading to jaw enlargement [9,10,11]. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice
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