Abstract
Background: The common gynaecological complaints encountered is dysfunctional uterine bleeding .Pipelle aspiration & Dilatation and curettage is done to find out the Histomorphological and its immunohistochemical alterations . Objective : This study aims to bring out the expression of Estrogen and Progesterone receptor in perimenopausal women of non-malignant and malignant endometrium presenting with menorrhagia. Result: Endometrial samples of 41 Perimenopausal women with AUB were also subjected to immunohistochemical staining to find out the Estrogen and Progesterone receptor status. Immunohistochemistry revealed the mean of PI values for ER and PR were highest in the proliferative endometrium (91.64% for ER; 94.38% for PR) followed by simple hyperplasia, complex hyperplasia, atypical hyperplasia and endometrial carcinoma (27.5% for ER; 27% for PR). Conclusion: Immunohistochemistry results in perimenopausal women show that the estrogen and progesterone receptor expression decreases progressively from proliferative endometrium to hyperplasias to endometrial carcinoma.
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