Abstract
ObjectivesThe aim of the study was to compare eight oxidative stress (OS) markers in serum and follicular fluid (FF) of infertile women with and without endometriosis (E) undergoing controlled ovarian stimulation (COS) for intracytoplasmic sperm injection (ICSI). Material and methodsEight‐seven serum samples (43 with E and 44 without E ‐ with male or tubal factor) and 61 FF samples (29 with E and 32 without E) were collected in the day of oocyte retrieval. Total hydroperoxides (FOX1), malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), superoxide dismutase (SOD) and the total antioxidant capacity (TAC) were determined by spectrophotometry, vitamin E (Vit E) by high performance liquid chromatography, and 8‐hydroxy‐2’–deoxyguanosine (8OHdG) by ELISA. ResultsWe observed higher serum concentrations of GSH (220.32±43.2 nmol/g pt) and SOD (677.9±282.21 U/mL), lower serum concentrations of TAC (0.34±0.17 mEq Trolox/L), and higher follicular concentrations of 8OHdG (23.19±6.8ng/mL) and Vit E (13.0±5.33μmol/L) in infertile women with E compared to those without E (193.92±43.25 nmol/g pt, 563.04±169.82 U/mL, 0.46±0.15 mEq Trolox/L, 17.22±5.6ng/mL and 8.71±2.51μmol/L, respectively). ConclusionsWe evidenced the occurrence of systemic and follicular OS in infertile patients with E undergoing COS for ICSI. We suggest that the OS may be involved in the etiopathogenesis of infertility‐related disease
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