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Abstract
The estradiol derived enyne 2 is obtained via a nine step sequence starting from estrone. Key-steps involve the opening of the α-epoxide 7 and the 1,2-addition of propargylmagnesium bromide on the allene ketone 10. The allylic alcohol 2 possesses the required functionalities for yielding, after dehydratation, the unsaturated core structure that is expected to cycloaromatize via Myers cyclization. So far, however, this elimination reaction has been unsuccessful.
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