Abstract
The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in developing hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30. This interaction is relevant for the control of neuronal differentiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis.
Highlights
Estradiol meets Notch signaling in developing neuronsMaría Angeles Arevalo, Isabel Ruiz-Palmero, Julia Simon-Areces, Estefanía Acaz-Fonseca, Iñigo Azcoitia and Luis Miguel Garcia-Segura1*
DEVELOPMENTAL ACTIONS OF ESTRADIOL Estradiol is a neuroactive steroid that exerts hormonal as well as local paracrine or autocrine actions in the central nervous system, during development and in adulthood
Activation of Notch signaling in neurons induces a decrease in the expression of neurogenin 3 (Ngn3) (Salama-Cohen et al, 2006)
Summary
María Angeles Arevalo, Isabel Ruiz-Palmero, Julia Simon-Areces, Estefanía Acaz-Fonseca, Iñigo Azcoitia and Luis Miguel Garcia-Segura1*. The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, regulates these developmental processes. We review recent evidence indicating that estradiol and Notch signaling interact in developing hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30. This interaction is relevant for the control of neuronal differentiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis
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