Estradiol in adult females and its association with depression: NHANES 2013-2016

Abstract

In the contemporary era of rapid global development, a growing proportion of individuals are dedicating extended hours to their professional endeavors, driven by the desire to attain enhanced financial remuneration and an improved quality of life. Consequently, a significant majority of the population finds themselves immersed in an environment characterized by elevated levels of stress and strain. Consequently, there is a growing prevalence of depression among individuals, with a particular emphasis on the female population. At present, there is a paucity of studies pertaining to the correlation between estradiol levels in women and the occurrence of depression. In order to investigate this issue, an experimental study is done to examine the relationship between estradiol levels and depression scores. The present study utilizes a sample derived from the 2013-2016 US National Health and Nutrition Examination Survey (NHANES) to investigate the relationship between estradiol levels and depression. This analysis employs various statistical techniques, including exploratory data analysis, linear regression, logistic regression, Poisson regression, and chi-squared test. Additionally, the study controls for several covariates, namely age, sex, race, marital status, work minutes, sedentary activity, vitamin D levels, and diabetes status. The findings indicate a negative association between estradiol levels and depression.