Abstract
To evaluate the estrogenic potential of secoisolariciresinol diglycoside (SDG) found in linseed meal (LSM) on visceral organ mass, IGF-I, and thyroid hormone (T 3 and T 4) concentrations, 48 multiparous, ovariectomized ewes (54.6 ± 1.1 kg) were used in a 3 × 4 factorial arrangement. Main effects were length of LSM feeding (0, 1, 7, or 14 d) and length of exposure to estradiol-17β (E 2) implant (0, 6, or 24 h prior to tissue collection). Implanting ewes with E 2 for 24 h increased liver mass relative to empty body weight (EBW; g/kg EBW) compared with ewes implanted for 0 or 6 h ( P ≤ 0.03), whereas feeding LSM for 14 d decreased liver mass compared with ewes fed LSM for 1 or 7 d ( P ≤ 0.02). There was an LSM × E 2 interaction ( P = 0.01) for duodenal mass (g/kg EBW), LSM, and E 2 tended ( P = 0.07) to influence the stomach complex mass; however, ileal mass was not affected. Neither LSM nor E 2 affected ( P ≥ 0.12) CYP2C or CYP3A mRNA expression or cellularity of the liver. Exogenous E 2 influenced circulating concentrations of IGF-I, T 3, and T 4. The estrogenic or anti-estrogenic potential of LSM is dependent upon the tissue, exposure to E 2, and the duration of LSM feeding. Feeding LSM during gestation, lactation, or during the grow-finish phase warrants further investigation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have