Estimation the protective role of Ginkgo biloba aqueous extract on some hormones and cerebellum tissue in male albino rats treated with aluminum chloride

Abstract

The current study aims to know the protective role of the aqueous extract of the Ginkgo biloba against cerebellum damage induced by Aluminum chloride (AlCl3) in male rats. 40 adult male rats were used, which were randomly divided into four equal groups (10 animals/group), the first group (G1) administered 1 ml/kg of tap water, the second group (G2) administered 10 mg/kg of AlCl3, the third group (G3) was administered 10 mg/kg of aqueous extract of the Ginkgo biloba (GBE), while the fourth group animals (G4) were administered 10 mg/kg of AlCl3 and 10 mg/kg of Ginkgo biloba aqueous extract orally and daily for 30 days. Fasting blood samples were collected after the end of the experiment to study the following parameters: concentration of Cortisol, Adrenocorticotropin hormone (ACTH) and growth hormone (GH). The results showed that oral administration of AlCl3 caused significant increase (P<0.05) in the concentration of Cortisol, ACTH and significant decrease (P<0.01) in the concentration of GH compared with the control group. Rats treated with GBE and that administration of AlCl3 with GBE showed no Significant difference (P<0.01) in the concentration of Cortisol, ACTH and GH.