Abstract
AbstractTo determine the in vivo neuropharmacological and in vitro antioxidant activities of methanolic extract of Tetracera sarmentosa. Open field (OFT), hole cross (HCT), thiopental-induced sleeping time (TIST), elevated plus-maze (EPMT) tests were used to determine the neuropharmacological activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, reducing power assay, total phenolic content tests were used to evaluate the in vitro antioxidant activity of T. sarmentosa. In the case of OFT and HCT, the extract showed a decrease in exploratory and locomotion activities at both dose levels (200 and 400 mg/kg body weight). In the thiopental-induced hypnosis test, 400 mg/kg dose of T. sarmentosa produced quick onset of sleep and prolonged duration of sleep than that of 200 mg/kg dose. T. sarmentosa extract showed the lessening percentage of entries of mice into the open arm and decreased percentage of time spent in open arm compared to the standard drug diazepam. In the case of DPPH sc...
Highlights
Medicinal plants are the prominent source of secondary metabolites as well as active drug compounds
Hole cross test (HCT) In the animal treated with methanol extract at 400 mg/kg dose showed a dose-dependent reduction in the locomotor activity and at higher dose, it was comparable with that of standard drug diazepam
Diazepam was used as the standard drug in the experimental animals to evaluate the CNS depressant effect of the plant extract
Summary
Medicinal plants are the prominent source of secondary metabolites as well as active drug compounds. Tetracera sarmentosa (Family: Dilleniaceae) is a scandent shrub which is generally found in Chittagong, Chittagong Hill Tracts, and Cox’s Bazar (Bangladesh Ethnobotany Online Database, n.d.) It is widely distributed through Southern China, India, Sri Lanka, Mayanmar, Thailand, Malaysia, and Indonesia (Flora of China, n.d.). In Sri Lanka, it is used as a healing agent for the treatment of bone fracture Antinociceptive activity of this plant was found when aqueous leaf extract was tested on rats (Fernando, Ratnasooriya, & Deraniyagala, 2009). Among them hexadecanoic acid (41.59%), phytol (11.10%), and linoleic acid (5.08%) are notable chemical components (Da, Zhu, Zhao, Teng, & Gan, 2014) In this modern era, anxiety, stress, and depression are the most common form of mental disorder. Methanolic plant extract of T. sarmentosa was evaluated to find its in vivo neuropharmacological and in vitro antioxidant activities
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