Abstract
BackgroundThe global burden of liver diseases, such as hepatocellular carcinoma and liver cirrhosis, is substantial. In this study, we estimated utility weights of liver disease-related health states in the general population using a visual analogue scale (VAS) and the standard gamble (SG) method.MethodsDepictions of standardized health states related to major liver diseases were developed based on patient education materials and previous publications. To fully reflect disease progression from diagnosis to prognosis, each health state comprised four parts: diagnosis, symptoms, treatment, and progression and prognosis. A total of 407 participants from the Korean general population evaluated the health states using the VAS and SG methods in computer-assisted personal interviews. After excluding illogical responses, mean utility weights were calculated for each health state.ResultsThe utility weights for health states were significantly different according to the existence of inconsistency in general. According to the VAS results, the health state with the highest utility was ‘Chronic hepatitis B virus infection’ (0.64), whereas the health state with the lowest utility was ‘Hepatocellular carcinoma that requires palliative therapy’ (0.17). Similarly, the SG results revealed that the health state with the highest utility was ‘Chronic hepatitis B virus infection’ (0.85), and the health state with the lowest utility was ‘Hepatocellular carcinoma that requires palliative therapy’ (0.40).ConclusionsThe estimated utility weights in this study will be useful to measure the burden of liver diseases and evaluate cost-utility of programs for reducing the burden of liver diseases.
Highlights
The global burden of liver diseases, such as hepatocellular carcinoma and liver cirrhosis, is substantial
In this study, the utility weights of various health states related to major liver diseases, such as liver cirrhosis (LC) and hepatocellular carcinoma (HCC), were estimated by using the visual analogue scale (VAS) and standard gamble (SG) methods among 407 participants recruited from the general population of Korea
In this study, we estimated the utility weights of 8 health states related to liver diseases, such as LC and HCC, using the VAS and SG methods, in the general population of Korea
Summary
The global burden of liver diseases, such as hepatocellular carcinoma and liver cirrhosis, is substantial. Burden of disease due to liver diseases, such as hepatocellular carcinoma (HCC) and liver cirrhosis (LC), is substantial, especially in developing countries [1]. Patients with liver diseases may experience various symptoms, such as fatigue and depression, and a diverse array of complications, such as ascites and varix bleeding [6, 7]. These symptoms and complications can lead to deterioration in the health-related quality of life. Management of liver diseases should focus on decreasing liver disease-associated mortality, and on improving health-related quality of life
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