Abstract
Extremely responsive technique designed for the willpower of trometamol for instance tris(hydroxymethyl) aminomethane in gadobutrol by RP-LC technique. Quantification of trometamol content in gadobutrol samples by HPLC with refractive index detector (RID). Trometamol was UV inactive compound. Trometamol was determined by RP-LC method using Inertsil NH2 (250x4.6mm, 5µm) column as motionless segment. Column temperature maintained 30°C, inoculation quantity 10µL, flow velocity was 0.3 ml/min, sample cooler temperature 25°C. The mixture of phosphate buffer and cyanomethane in the ratio of 990:10 (volume/volume) was utilized as movable segment. The technique legalization erstwhile conceded as indicated by ICH guidelines.
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