Abstract
The parameters for a three-compartment model described by Morse and colleagues [...].
Highlights
Dexmedetomidine was administered using a well-considered informative study design that involved target-controlled infusion with increasing target concentrations: 1, 2, 3, 4, 6, and 8 ng/mL—arterial plasma concentrations that often exceed those used clinically. Both the Morse [1] and Hannivoort [2] parameter sets nicely describe the observations from their cohort populations
The larger V1 is consistent with most previous studies in adult patients, there is concern about the use of this V1 parameter to determine a loading dose to rapidly achieve a target concentration during target-controlled infusion
Classical teaching is that loading dose can be calculated for a one-compartment model by using volume of distribution (V) and target concentration (CTARGET )
Summary
Estimation of the Loading Dose for Target-Controlled Infusion of Dexmedetomidine. “Morse et al A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults. Pharmacokinetic Model for Dexmedetomidine in Children and Adults. The parameters for a three-compartment model described by Morse and colleagues [1]
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