Abstract
A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation.
Highlights
A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution
The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode
The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte
Summary
Plant Tissue Culture: Methods and Applications in Agriculture. Chemical regulation of growth and organ formation in plant tissues cultured In vitro. Editors Economical and Medicinal Plant Research, Vol.1 New York: Academic Press; 1985. Estimation of Tegaserod Maleate by Differential Pulse Polarography
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