Abstract
Background: Osteoporosis (OP) is a systemic disease characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in an increased risk of fractures and has touched rampant proportions. Osteocalcin, one of the osteoblast-specific proteins, showed that its functions as a hormone improves glucose metabolism and reduces fat mass ratio. This study is aimed to estimate the osteocalcin and glucose level in blood serum of osteoporotic postmenopausal Women with and without Type 2 Diabetes.Materials and methods: 60 postmenopausal women with osteoporosis divided into two groups depending on with or without T2DM, 30 patients for each. Serum samples of 30 healthy postmenopausal women were collected as control group. Osteocalcin was measured by ELISA method using a kit of (CUSABIO. China). Glucose was determined by spectrophotometric method. Results: Mean serum osteocalcin in postmenopausal osteoporotic women without Type II Diabetes is higher than control group and the group with T2DM (p ? 0.001). Conclusion: Bone formation marker increases at postmenopausal osteoporosis women; Hyperglycemia also induces osteoblast function and reduces of production osteocalcin at T2DM.
Highlights
Osteoporosis is a systemic disease characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in an increased risk of fracture and has touch rampant proportions [1]
The results showed that WC of A group is significantly higher than B and control groups, [P < 0.001], WC of B group is significantly higher than control groups, [P < 0
This study revealed that serum osteocalcin level in postmenopausal women was significantly higher than control group
Summary
Osteoporosis is a systemic disease characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in an increased risk of fracture and has touch rampant proportions [1]. Diabetes mellitus is a common disease in most parts of the world [4] It affects skeletal system and bone metabolism through multiple pathways and it has been recognized as a major risk factor for osteoporosis [5]. Poor glycemic control can induce hypercalciuria which has been considered a potential risk factor for osteoporosis in patients with type 2 diabetes [6]. This study is aimed to estimate the osteocalcin and glucose level in blood serum of osteoporotic postmenopausal Women with and without Type 2 Diabetes. Results: Mean serum osteocalcin in postmenopausal osteoporotic women without Type II Diabetes is higher than control group and the group with T2DM (p ≤ 0.001). Conclusion: Bone formation marker increases at postmenopausal osteoporosis women; Hyperglycemia induces osteoblast function and reduces of production osteocalcin at T2DM
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