Estimation of Serum Cystatin-C as early marker of Kidney Dysfunction in correlation with Serum Ferritin among ?- Thalassemia Major Patients

Abstract

The Cystatin C is early predictor for evaluation the kidney functions. The Serum Cystatin C is a cysteine proteinase inhibitor, that the nucleated cells produce it at stable rate. It is filtered through the glomerular filtration membranes of kidneys, and the filtration rate will be unaffected by external factors. A group of recessively inherited hemoglobin disorders called Major Beta-thalassemia and considered the most common genetic disorder all over the world, which could be noticed by the reduction in of ?-globin chain synthesis.Objective: To study Serum Cystatin-C estimation as early marker of renal function in relation with other parameters in beta thalassemia patients.Materials and Method: A case-control study was executed on thalassemia patients between February and April 2019 at Al-Zahra’a Teaching Hospital in Najaf/Iraq.Results: the results in this study showed there are significant differences (p< 0.05) between major beta thalassemia patients and control group in regarding to hematological parameters. The result of biochemical parameters showed there are variations between patients and control where there were significant statistical increases in our thalassemic patients comparing to the control about Cystatin-C (1.27±0.33and 0.7±0.24 ng\ml respectively).Conclusion: the cystatin –C is useful marker at major beta thalassemia patients that suffering from renal dysfunction