Abstract
The aim of the present study was to estimate the serum status of antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in oral submucous fibrosis (OSF) which is a precancerous condition common in Indian subcontinent. A total of sixty subjects were included in the study comprising of 30 cases of oral submucous fibrosis and 30 healthy controls. The haemolysate levels of antioxidant enzymes (SOD and GPX) were estimated using Ciba corning express plus autoanalyzer for spectrometry. In OSF, serum antioxidant enzyme levels were found to be decreased (mean SOD 86.63±20.36 and mean GPX 1.50±0.30 U/ml) compared to the control group (mean SOD 127.1±18.14 and mean GPX 2.71±0.43 U/ml). The results suggest that low values of SOD and GPX may be associated with the development of carcinoma in oral submucous fibrosis.
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