Estimation of Serum Alkaline Phosphatase, Total Calcium and Urinary Hydroxyproline as Bone turn over marker in Post-Menopausal women in Tertiary care Hospital

Abstract

Background: Osteoporosis is one of the prevalent diseases of post-Menopausal women. Hence to evaluate the severity of osteoporosis serum calcium, serum ALP and urinary hydroxyproline used as bone resorption marker.Method: 30 post-menopausal women with osteoporosis were compared with healthy pre-menopausal 25-40 years of women. Random Blood sample collected from venipuncture and centrifuged to get serum. Fasting Urine sample was collected and 1.2 drops 6 N HCI was added as preservative. The parameter compared between preand post menopausal were, serum calcium, alkaline phosphatase, total protein, Albumin, Urine test included Hydroxyproline,creatinine and results were noted.Results: Comparison of S. calcium, S.alkalinePhosphatase, S. Protein,S. Albumin and Urinary hydroxyproline. Urinary creatinine were compared and every parameters had highly significant p value (p<0.001).Conclusion: These results demonstrate that biochemical markers of bone turn over like serum total ALP total calcium provide dynamic measure of bone remodelling and helps to predict the changes in bone mass and fracture of risk in post-menopausal women.