Abstract
Aims To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft–Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae. Materials and methods Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft–Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR ≤ 50 ml/min was also carried out. Results The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group. Conclusions The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (≤50 ml/min), the formulae have similar accuracy.
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