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Abstract
The aimis to carry out an automated analysis of biological liquids for the estimation of metastatic neogenesis in ascitic exudates.Materials and methods.A retrospective analysis of 40 case histories of patients with the ascitic syndrome of non-tumour (cirrhotic) and tumour genesis was performed. Traditional cytology was accompanied by an automated analysis of exudative fluids. The final diagnosis was verified using instrumental and pathomorphological methods. The processing of statistical data included an assessment of the intergroup difference significance.Results.Compared with cirrhotic ascites, the following parameters of the automated analysis of biological fluids are found to be statistically significant (p30% in the atypical cell screening system has been established. In the absence of an acute inflammatory reaction, the presence of eosinophils in the exudate should be interpreted as an indirect marker of a tumour process. According to the data obtained, the content of neutrophils, lymphocytes and monocytes in ascitic fluids does not depend on the nature of the process (p>0.05).Conclusion.The diagnostic capabilities of automated analysis of ascitic fluids are analysed. In the system of differential diagnosis of tumour and non-tumour processes, the following parameters are established to possess the greatest informative value: TCN, HF, and the presence of eosinophils (EO).Conflict of interest: the authors declare no conflict of interest.
Highlights
In the absence of an acute inflammatory reaction, the presence of eosinophils in the exudate should be interpreted as an indirect marker of a tumour process
According to the data obtained, the content of neutrophils, lymphocytes and monocytes in ascitic fluids does not depend on the nature of the process (p>0.05)
Установлено, что наибольшей информативной ценностью обладает следующий комплекс параметров: показатель общего цитоза; содержание эозинофилов, количество высокофлуоресцентных мононуклеарных клеток
Summary
Тем не менее результаты ряда специальных исследований свидетельствуют об удовлетворительной прогностической ценности показателя HF при скрининге атипических клеток в биологических жидкостях [9,10,11]. По мнению ряда авторов, отсутствие в биологической жидкости высокофлуоресцентных мононуклеаров с большой долей вероятности свидетельствует о доброкачественной природе выпота [2, 11]. Исследовались следующие параметры автоматизированного анализа биологических жидкостей: показатель общего цитоза (TCN, 109/л); содержание лейкоцитов (WBC, 109/л), количество эритроцитов (RBC, 1012/л); абсолютное и относительное количество мононуклеарных клеток (MN,109/л и MN%); абсолютное и относительное количество полисегментоядерных клеток (PMN, 109/л и PMN%); абсолютное и относительное количество мононуклеарных клеток с высокой флуоресценцией (HF, 109/л и HF%); абсолютное и относительное количество нейтрофилов (NE, 109/л и NE%); абсолютное и относительное количество лимфоцитов (LY, 109/л и LY%); абсолютное и относительное количество моноцитов (MO, 109/л и MO%); абсолютное и относительное количество эозинофилов (EO, 109/л и EO%).
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